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A strong immunolabeling was found for collagen IV and Iba at the ischemic core, diminishing towards the border zone and the control region, while most impressive GFAP-immunostaining was seen at the ischemic border zone in terms of a glial scar formation.

8 Institute of Cellular and Integrative Neurosciences, CNRS UPR 3212, University of Strasbourg, 5 rue Blaise Pascal, Strasbourg Cedex, 67084, France.

Treatment with PEDF was found to significantly attenuate the usually detected up-regulation of collagen IV in ischemia-affected subcortical regions, whereas EGF did not influence collagen IV expression as compared to the control group.

21-23, 91054 Erlangen Gesundheitszentrum St.

166, 73760 Ostfiltern Ruit Frauenklinik der St.

GFAP-immunoreactivity appeared decreased in areas of ischemia-related tissue damage of both the striatum and the neocortex A, B.

Thereby, the integrity of the vasculature in close relation to neighboring structures like astrocytes appears as a promising target.

Rats underwent 60 minutes of focal cerebral ischemia.

Therefore they may be utilized as prognositc biomarkers for prognostic evaluation of therapy planning.